Calculators · Oncology · Dose

Carboplatin dose — Calvert formula

Also called Calvert formula, carboplatin AUC dosing, AUC dosing

Carboplatin dose from target AUC and GFR, with a Cockcroft–Gault GFR option and the FDA 125 mL/min cap.

mg/mL·min
GFR source
mL/min
years
Sex (for Cockcroft–Gault)

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Formula and scoring

Dose (mg) = target AUC × (GFR + 25). Cockcroft–Gault: CrCl (mL/min) = (140 − age) × weight (kg) × [0.85 if female] ÷ (72 × SCr mg/dL). FDA: cap estimated GFR at 125 mL/min → maximum dose = AUC × 150 mg.

Exam and ward pearls

  • The "+25" is non-renal clearance; Calvert’s first formula was AUC × (1.2 × GFR + 20).
  • Maximum doses with the cap: AUC 6 → 900 mg, AUC 5 → 750 mg, AUC 4 → 600 mg.

When not to rely on it

  • Calvert derived the formula with measured GFR. Cockcroft–Gault estimates creatinine clearance and is a surrogate, less reliable at extremes of weight and in unstable renal function.
  • A very low serum creatinine inflates the estimate; follow your unit’s protocol on minimum creatinine values.

Source

  1. Calvert AH, Newell DR, Gumbrell LA, et al. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol. 1989;7(11):1748-56. doi:10.1200/JCO.1989.7.11.1748 · PMID 2681557
  2. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41. doi:10.1159/000180580 · PMID 1244564
  3. US Food and Drug Administration. Carboplatin dosing (IDMS creatinine; cap estimated GFR at 125 mL/min). Archived page, last updated 27 Nov 2015. Link
  4. Samani A, Bennett R, Eremeishvili K, et al. Glomerular filtration rate estimation for carboplatin dosing in patients with gynaecological cancers. ESMO Open. 2022;7(2):100401 (Table 1: Cockcroft–Gault form). doi:10.1016/j.esmoop.2022.100401 · PMID 35227967

Formula and cut-offs checked against these sources on 8 Nov 2026. Educational tool for clinicians; it does not replace clinical judgement.

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