Dermatology
Other Viral Diseases
Built from Dermatology, 5th Edition

What’s inside
16 sections · 172 slides
Overview
- What is a viral exanthem?
- Relative size and shape of viruses that infect the skin
- Nonspecific viral exanthems
- Diagnostic approach to a morbilliform (measles-like) exanthem
Enterovirus Infections
Hand-foot-and-mouth disease, herpangina, and other exanthems
- Enterovirus infections: key features
- How enterovirus infection spreads in the body
- Clinical manifestations of enterovirus infection
- Hand-foot-and-mouth disease (HFMD)
- Hand-foot-and-mouth disease, including the coxsackievirus A6 variant
- Coxsackievirus A6 (CVA6): an atypical HFMD
- Coxsackievirus A6 infection: additional presentations
- Hand-foot-and-mouth disease: finger and palm involvement
- Hand-foot-and-mouth disease: palmar vesicles
- Coxsackievirus A6 infection: sole involvement in adults
- Herpangina
- Other enteroviral exanthems
- Widespread non-blanching enteroviral exanthem
- Diagnosis of enterovirus infection
- Serologic assays of antibody responses
- Treatment of enterovirus infection
Measles
Rubeola: a vaccine-preventable exanthem that still causes outbreaks
- Measles: key features
- Measles: prodrome and Koplik spots
- Measles exanthem
- Measles: cephalocaudad spread and complications
- Atypical measles
- Measles: treatment and prevention
Rubella
German measles: mild in most, dangerous for the unborn fetus
- Rubella: key features
- Rubella: clinical features
- Rubella: joint and organ complications
- Congenital rubella syndrome
- Rubella virus persisting after immunodeficiency or vaccination
- Rubella: treatment and prevention
Erythema Infectiosum
Fifth disease: parvovirus B19 and its many faces
- Parvovirus B19: history and overview
- Parvovirus B19: how it spreads and infects
- Course of parvovirus B19 infection
- Parvovirus B19: viremia, antibodies, and rash timing
- Erythema infectiosum: the classic rash
- Erythema infectiosum: slapped cheeks and the lacy eruption
- Erythema infectiosum: the lacy pattern on the upper arm
- Papular-purpuric gloves and socks syndrome (PPGSS)
- Papular-purpuric gloves and socks syndrome
- PPGSS: petechiae on the sole
- Parvovirus B19: joint disease and fetal infection
- Parvovirus B19 clinical associations
- Parvovirus B19 clinical associations (continued)
- Parvovirus B19: diagnosis and treatment
Roseola Infantum
Sixth disease: high fever in infants, rash after the fever breaks
- Roseola infantum: key features
- Roseola infantum: clinical course
Unilateral Laterothoracic Exanthem
A one-sided rash of unknown but likely viral cause
- ULTE: key features and epidemiology
- Unilateral laterothoracic exanthem
- ULTE: cause, course, and differential diagnosis
Gianotti-Crosti Syndrome
A symmetric papular eruption triggered by many different viruses
- Gianotti-Crosti syndrome: history and key features
- Gianotti-Crosti syndrome
- Gianotti-Crosti syndrome: facial involvement
- Gianotti-Crosti syndrome: epidemiology and pathogenesis
- Potential etiologies reported in association with Gianotti–Crosti syndrome
- Potential etiologies reported in association with Gianotti–Crosti syndrome (continued)
- Gianotti-Crosti syndrome: clinical features
- Gianotti-Crosti syndrome: differential diagnosis and treatment
Poxvirus Infections
Smallpox, mpox, orf, and molluscum contagiosum
- The poxvirus family
- Smallpox: a lingering bioterrorism concern
- Eight poxvirus infections of humans
- Smallpox: poxvirus profile
- Smallpox: poxvirus profile (continued)
- Vaccinia: poxvirus profile
- Vaccinia: poxvirus profile (continued)
- Mpox (previously monkeypox): poxvirus profile
- Mpox (previously monkeypox): poxvirus profile (continued)
- Cowpox: poxvirus profile
- Cowpox: poxvirus profile (continued)
- Orf: poxvirus profile
- Orf: poxvirus profile (continued)
- Milker's nodules: poxvirus profile
- Deer-associated parapoxvirus infection: poxvirus profile
- Deer-associated parapoxvirus infection: poxvirus profile (continued)
- Tanapox: poxvirus profile
- Cutaneous reactions to smallpox (vaccinia) vaccination
- Ulceration at a vaccinia vaccination site
- Comparison of varicella/disseminated zoster to smallpox
- Mpox (monkeypox): clinical picture
- Clinical spectrum of mpox lesions
- Histopathologic findings in mpox
- Widespread mpox infection in a patient with atopic dermatitis
- Orf, milker's nodules, cowpox, and tanapox
- Orf: hand lesion and histology
- Orf: vesiculopustule on the finger
- Molluscum contagiosum: the last poxvirus of humans
- Molluscum contagiosum: lesions, dermatitis, and histology
- Molluscum contagiosum: inflamed lesions and associated dermatitis
- Molluscum contagiosum: numerous lesions with atopic dermatitis
- Molluscum contagiosum: diagnosis and differential
- Treatment of molluscum contagiosum
- Treatment of molluscum contagiosum (continued)
- Treatment of molluscum contagiosum (continued)
- Molluscum contagiosum: newer treatments
Viral Hemorrhagic Fevers, Including Dengue
Zoonotic viral illnesses ranging from mild fever to life-threatening shock
- Viral hemorrhagic fevers: overview
- Eight viral hemorrhagic fevers compared
- Lassa fever: epidemiologic profile
- New World arenaviruses (Junin, Machupo, Guanarito, Sabia): epidemiologic profile
- Ebola virus disease: epidemiologic profile
- Marburg virus disease: epidemiologic profile
- Hantavirus infection: epidemiologic profile
- Crimean-Congo hemorrhagic fever: epidemiologic profile
- Rift Valley fever: epidemiologic profile
- Yellow fever: epidemiologic profile
- Dengue: clinical features
- Geographic distribution of dengue
- Severe dengue: DHF and DSS
- Dengue: diagnosis and vaccines
West Nile, Zika, Chikungunya, and Related Viruses
Mosquito-borne viral infections with distinctive skin signs
- West Nile virus infection
- Zika virus infection
- Chikungunya fever
- Barmah Forest and Ross River virus infections
- Mosquito-borne viral infections compared
Cutaneous Manifestations of Hepatitis A, B, and C
Skin findings that can point to an underlying liver infection
- Hepatitis viruses and the skin
- Cutaneous manifestations of hepatitis B and/or C infection
Polyomavirus Infections
Trichodysplasia spinulosa and other skin disease from human polyomaviruses
- Human polyomaviruses: an emerging group
- Trichodysplasia spinulosa: clinical features
- Cutaneous polyomavirus infections: spiny papules and HPyV6 spicules
- Trichodysplasia spinulosa in a renal transplant recipient
- Pruritic and dyskeratotic dermatoses (PDD)
- HPyV7-associated pruritic dermatosis: skin biopsy findings
- HPyV7-associated pruritic dermatosis: clinical appearance
- Polyomavirus skin disease: treatment
Rabies
No skin rash, but dermatologists may be asked to biopsy nuchal skin
- Rabies and the dermatologist's role
- Pathogenesis of rabies infection
Cutaneous Manifestations of SARS-CoV-2 Infection
Skin findings of COVID-19 and its vaccines, plus MIS-C in children
- SARS-CoV-2 infection: skin involvement overview
- Cutaneous manifestations of SARS-CoV-2 infection and vaccination
- Cutaneous manifestations of SARS-CoV-2 infection and vaccination (continued)
- Cutaneous manifestations of SARS-CoV-2 infection and vaccination (continued)
- Cutaneous manifestations of SARS-CoV-2 infection and vaccination (continued)
- Urticaria associated with SARS-CoV-2 infection
- Delayed local reaction ("COVID arm") to an mRNA vaccine
- Multisystem inflammatory syndrome in children (MIS-C)
- MIS-C: 2023 CDC diagnostic criteria
- MIS-C: 2023 CDC diagnostic criteria (continued)
- MIS-C: 2023 CDC diagnostic criteria (continued)
- MIS-C versus Kawasaki disease
- MIS-C versus Kawasaki disease (continued)
- MIS-C versus Kawasaki disease (continued)
Kawasaki Disease
An acute febrile illness that can silently damage the coronary arteries
- Kawasaki disease: history and importance
- Kawasaki disease: epidemiology
- Kawasaki disease: pathogenesis theories
- Kawasaki disease: diagnostic criteria
- Kawasaki disease: diagnosis requires the fever plus 4 of 5
- Kawasaki disease: perineal, palmar, and truncal findings
- Kawasaki disease: urticarial rash and chapped lips
- Kawasaki disease: early clinical clues
- Facial findings: Kawasaki disease versus staphylococcal scalded skin syndrome and erythema multiforme major
- Kawasaki disease: conjunctival and oral findings
- Kawasaki disease: cardiac and other organ involvement
- Incomplete (atypical) Kawasaki disease
- Kawasaki disease: first-line treatment
- Kawasaki disease: refractory disease
- Kawasaki disease: long-term outlook
- Classic childhood exanthems: quick recall
- Key take-home points
- References
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- Dermatology, 5th Edition (2-Volume Set)