Dermatology
Other Vesiculobullous Diseases
Built from Dermatology, 5th Edition
What’s inside
11 sections · 73 slides
Overview
- What counts as an 'other' vesiculobullous disease
- How this topic is organised
Bullosis Diabeticorum
Sudden, spontaneous blisters on normal-looking skin in people with diabetes mellitus
- Key features of bullosis diabeticorum
- History and epidemiology
- Pathogenesis: why the blisters form
- Clinical features
- Bullosis diabeticorum: tense bulla over the medial malleolus
- Bullosis diabeticorum on the palm
- Pathology: what the biopsy shows
- Differential diagnosis
- Treatment
Coma Blisters
Pressure blisters that develop in unconscious, immobile, or neurologically impaired patients
- Key features of coma blisters
- A short history
- Causes of coma blisters
- Pathogenesis: pressure or drug toxicity
- Coma bullae at a pressure site
- Neurologic blisters on the hemiplegic hand
- Sweat gland necrosis in a pressure-induced bulla
- Telling coma blisters and friction blisters apart
- Complications and treatment
Friction Blisters
The everyday blister - caused by repeated rubbing, most often on the feet
- Key features and epidemiology
- 33%
- Pathogenesis: how rubbing makes a blister
- Clinical features
- Friction blister from a ski boot
- Friction blister from a knife handle
- Pathology
- Differential diagnosis and treatment
Bullous Cutaneous Small Vessel Vasculitis
When blood-vessel inflammation in the skin becomes severe enough to blister
- Overview
- Bullous cutaneous small vessel vasculitis
- Bullous vasculitis with chronic leg edema
- Vesicles within a purpuric plaque in IgA vasculitis
- Pathology
Bullous Drug Eruptions
A reminder that many different drug reactions - not just one disease - can present with blisters
- Key features
- Bullous drug eruptions
- Ofloxacin-induced linear IgA bullous dermatosis
Bullous Insect Bite Reactions
From an everyday bite that blisters, to severe exaggerated reactions in blood cancers
- Key features
- History and who is affected
- Pathogenesis: from first bite to blister
- Special mechanisms in blood cancers
- Clinical features
- Bullous insect bite reaction at the ankle
- Exaggerated insect bite reaction in chronic lymphocytic leukemia
- Bullous insect bite mimicking localized bullous pemphigoid
- Multiple bullous insect bites on the distal leg
- Generalized bullous bedbug bite reaction
- Hemorrhagic vesicles in chronic lymphocytic leukemia
- Histopathology of a bullous bug bite reaction
- Pathology in detail
- Differential diagnosis and treatment
Delayed Postburn/Postgraft Blisters
Blisters that appear weeks after burned or grafted skin has already finished healing
- Key features
- Epidemiology
- Pathogenesis: an 'immature' skin junction
- Timing of the blisters
- Pathology and differential diagnosis
- Treatment
Edema Blisters
Blisters that form when longstanding leg swelling suddenly gets worse
- Key features
- Epidemiology and pathogenesis
- Clinical features
- Edema bulla on an infant's thigh
- Edema bulla with lower extremity edema
- Pathology, differential diagnosis, and treatment
Additional Vesiculobullous Disorders
Fracture blisters, sucking blisters, self-inflicted blisters, jellyfish stings, and light-treatment blisters
- Overview
- Additional vesiculobullous disorders
- Fracture blisters after blunt thigh trauma
- Fracture blisters over edematous skin
Putting It Together
A single diagnostic map for the bland (non-inflamed) bulla of the distal lower leg
- Diagnostic approach to bland bullae of the distal lower extremities
- Key take-home points
- References
- References (continued)
- References (continued)
- References (continued)
- Dermatology, 5th Edition (2-Volume Set)