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The first 25 slides, exactly as they appear. The full deck has 87 content slides.
Dermatology
Graft-versus-Host Disease
Built from Dermatology, 5th Edition
What’s inside
8 sections · 87 slides
Overview
- What this topic covers
- Key features
Stem Cell Transplant and GVHD
Background, history and epidemiology
- What is graft-versus-host disease
- Diseases treated with allogeneic stem cell transplant
- Primary disorders treated with allogeneic hematopoietic stem cell transplantation
- History of stem cell transplant
- Epidemiology of GVHD
- Where the stem cells come from
- Other transplant trends that shape GVHD
- ~80%
Pathogenesis
How donor and host immune cells cause disease
- Acute GVHD: a three-step immune attack
- A second acute GVHD pathway
- Chronic GVHD: less understood, more autoimmune-like
- B cells and autoantibodies in chronic GVHD
- Regulatory T cells and Th17 cells in chronic GVHD
Acute Graft-versus-Host Disease
Clinical features, staging and pathology
- How acute GVHD looks on the skin
- Clinical spectrum of acute cutaneous graft-versus-host disease
- Staging acute GVHD severity
- Clinical staging of acute graft-versus-host disease (aGVHD)
- Clinical staging of acute graft-versus-host disease (aGVHD) (continued)
- Clinical staging of acute graft-versus-host disease (aGVHD) (continued)
- Grading acute GVHD and its outlook
- Skin biopsy findings in acute GVHD
- Acute cutaneous GVHD - histopathologic grades
- Mimics of acute GVHD
- Engraftment syndrome versus acute GVHD
- Clinical features of engraftment syndrome versus acute graft-versus-host disease (GVHD)
- Clinical features of engraftment syndrome versus acute graft-versus-host disease (GVHD) (continued)
- Treatment of acute GVHD
Chronic GVHD - Skin Disease
A remarkably variable, multi-pattern condition
- Chronic GVHD affects nearly any organ
- Multi-organ manifestations of chronic graft-versus-host disease
- Acute versus chronic: a blurring distinction
- Diagnostic criteria for chronic GVHD
- Diagnostic mucocutaneous manifestations of chronic graft-versus-host disease (based on NIH Consensus Criteria 14 )
- The main skin patterns of chronic GVHD
- Clinical spectrum of chronic cutaneous graft-versus-host disease
- Lichen planus-like chronic GVHD
- Other epidermal patterns of chronic GVHD
- Well-demarcated pink-violet plaques at pressure areas in chronic GVHD
- Sclerotic-pattern chronic GVHD: an overview
- Lichen sclerosus-like chronic GVHD
- Lichen sclerosus-type chronic cutaneous GVHD
- Morphea-like chronic GVHD
- Morpheaform chronic GVHD across the trunk
- Morpheaform chronic GVHD in a diapered child
- Scleroderma-like chronic GVHD
- Bound-down, sclerotic skin of the hand and wrist
- Scleroderma-like (sclerodermoid) chronic GVHD
- Eosinophilic fasciitis-like chronic GVHD
- Rippled skin texture in eosinophilic fasciitis-like chronic GVHD
- Eosinophilic fasciitis-like presentation - second example
- Imaging fascia involvement in chronic GVHD
- MRI of eosinophilic fasciitis-like chronic GVHD before and after treatment
- Histology of sclerotic-pattern chronic GVHD
- Morphea-like chronic GVHD - histologic features
- Additional cutaneous manifestations of chronic GVHD
- Additional cutaneous manifestations of chronic graft-versus-host disease (cGVHD)
- Vitiligo and hyperpigmentation in chronic GVHD
- Vitiligo, scarring alopecia and nail dystrophy in chronic GVHD
- Residual dyspigmentation after epidermal chronic GVHD
Mucosal, Nail and Additional Findings
Mouth, genital, nail and hair involvement
- Oral involvement in chronic GVHD
- Genital involvement in chronic GVHD
- Orogenital involvement in chronic cutaneous GVHD
- Oral lichen planus-like pattern and a healing morphea-like ulcer
- Nail and hair changes in chronic GVHD
Differential Diagnosis and Risk Factors
What else can look like chronic GVHD
- Mimics of chronic cutaneous GVHD
- Sclerotic chronic GVHD versus systemic sclerosis
- Comparison of clinical and laboratory features of sclerotic-type chronic GVHD (cGVHD) and systemic sclerosis
- Comparison of clinical and laboratory features of sclerotic-type chronic GVHD (cGVHD) and systemic sclerosis (continued)
- Risk factors for developing GVHD
- Risk factors associated with the development of graft-versus-host disease (GVHD)
Treatment of Chronic GVHD
Skin-directed, systemic and supportive care
- Treatment strategy for chronic GVHD
- Skin-directed treatment of chronic GVHD
- Systemic first-line treatment of chronic GVHD
- Second-line and refractory chronic GVHD treatment
- Site-specific and multidisciplinary care
- Sun protection and skin cancer risk
- Patient handout: general skin care recommendations
- Patient handout – general dermatologic recommendations for patients with cutaneous graft-versus-host disease (GVHD)
- Patient handout – general dermatologic recommendations for patients with cutaneous graft-versus-host disease (GVHD) (continued)
- Patient handout – general dermatologic recommendations for patients with cutaneous graft-versus-host disease (GVHD) (continued)
- Key takeaways
- References
- References (continued)
- References (continued)
- References (continued)
- Dermatology, 5th Edition (2-Volume Set)