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The first 25 slides, exactly as they appear. The full deck has 78 content slides.
Dermatology
Eosinophil-Associated Dermatoses
Built from Dermatology, 5th Edition
What’s inside
4 sections · 78 slides
Eosinophils in the skin
From basic biology to Wells syndrome and the hypereosinophilic syndromes
- What this chapter covers
- What is an eosinophil
- Why the name "eosinophil"
- Granules and surface receptors
- Priming cytokines that activate eosinophils
- Where the activating cytokines come from
- How eosinophils reach the skin
- Eosinophil recruitment to the skin
- Degranulation: emptying the toxic cargo
- Three mechanisms of degranulation
- Toxic granule proteins and what they do
- Eosinophils beyond inflammation
- Eosinophils talking to other cells
Eosinophil-associated dermatoses
Skin diseases in which eosinophils are the diagnostic clue
- What counts as an eosinophil-associated dermatosis
- Working up eosinophil-rich skin infiltrates
- Evaluating eosinophil-rich cutaneous infiltrates
- A wide differential: eosinophil-associated dermatoses
- Eosinophil-associated dermatoses
- Eosinophil-associated dermatoses (continued)
- Eosinophil-associated dermatoses (continued)
- Eosinophil-associated dermatoses (continued)
- Eosinophil-associated dermatoses (continued)
- Eosinophil-associated dermatoses (continued)
- Eosinophil-associated dermatoses (continued)
- Eosinophil-associated dermatoses (continued)
- Eosinophil-associated dermatoses (continued)
- Eosinophil-associated dermatoses (continued)
- Eosinophil-associated dermatoses (continued)
- IgG4-related disease and the skin
- IgG4-related disease and skin disorders with raised IgG4+ plasma cells
- IgG4-related disease and skin disorders with raised IgG4+ plasma cells (continued)
- IgG4-related disease and skin disorders with raised IgG4+ plasma cells (continued)
Wells Syndrome
Eosinophilic cellulitis: plaques that look infected but are not
- Wells syndrome at a glance
- History of the name
- What triggers Wells syndrome
- Clinical appearance
- Course of a Wells syndrome plaque
- Flame figures on biopsy
- Telling Wells syndrome apart from its mimics
- Eosinophilic annular erythema (EAE)
- Treating Wells syndrome
- Newer biologic treatments
- Mechanism of anti-IL-5 monoclonal antibodies
Hypereosinophilic Syndromes
When eosinophils flood the blood and damage organs
- Hypereosinophilic syndrome (HES) at a glance
- Defining HES
- Who gets HES
- Three families of HES
- The three diagnostic criteria for HES
- Diagnostic criteria for hypereosinophilic syndromes
- Variants of hypereosinophilic syndrome
- Myeloid HES (MHES) — primary, neoplastic features
- Lymphocytic HES (LHES) — secondary features
- Associated (secondary, reactive) HES — features
- Overlap HES — syndromes resembling idiopathic HES
- Overlap HES — eosinophilic disease restricted to another organ
- Typical skin and system findings in HES
- What the biopsy shows in HES
- Distinguishing HES from EGPA and parasitic disease
- HES versus ordinary urticaria and angioedema
- First steps in treating HES
- Targeted therapy: imatinib
- Treating secondary (reactive) HES
- Monoclonal antibodies for HES
- Classifying and treating hypereosinophilic syndromes
- Other diseases where flame figures appear
- Entities in which flame figures may be seen
- Entities in which flame figures may be seen (continued)
- Key takeaways
- References
- References (continued)
- References (continued)
- References (continued)
- References (continued)
- References (continued)
- References (continued)
- References (continued)
- References (continued)
- Dermatology, 5th Edition (2-Volume Set)