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Dermatology
Cutaneous Vasculitis
Built from Dermatology, 5th Edition
What’s inside
6 sections · 76 slides
Overview
- What this topic covers
Classification and Pathogenesis
How vessel size predicts the clinical picture, and the two ways vessels get damaged
- What vasculitis is
- Vessel size sets the clinical picture
- Vasculitis by vessel size
- Why classify by vessel size
- Cutaneous vasculitis classification: subtypes by vessel size
- Cutaneous vasculitis classification: subtypes by vessel size (continued)
- Cutaneous vasculitis classification: lesion appearance by subtype
- Epidemiology of cutaneous vasculitis
- ~45/million
- Two ways a blood vessel gets attacked
- Immune complex versus ANCA-mediated injury
- Immune complex-mediated versus ANCA-mediated vessel injury
Clinical Features and Pathology
What the lesions look like, how to biopsy them, and what the biopsy shows
- Small vessel disease: what it looks like
- Medium vessel disease: what it looks like
- Cutaneous small vessel vasculitis: clinical spectrum
- Clinical variants of cutaneous small vessel vasculitis
- Systemic symptoms that go with vasculitis
- Biopsy timing and technique
- Leukocytoclastic vasculitis (LCV) under the microscope
- Why palpable purpura looks the way it does
- Cutaneous small vessel vasculitis: histopathology
- Biopsy clues that hint at a cause
- What direct immunofluorescence shows
- Lymphocytic and granulomatous patterns
- Lymphocytic vasculitis
- Conditions that mimic vasculitis
- Clinical differential diagnosis of cutaneous vasculitis
- Clinical differential diagnosis of cutaneous vasculitis (continued)
Cutaneous Small Vessel Vasculitis
The single-organ, skin-limited small vessel subtype - epidemiology, presentation, and treatment
- Cutaneous small vessel vasculitis (CSVV)
- CSVV: epidemiology and pathogenesis
- Clinical presentation of CSVV
- Symptoms and healing of CSVV lesions
- Systemic involvement in CSVV
- ~90%
- What predicts chronic CSVV
- Etiologies of cutaneous small vessel vasculitis
- Cutaneous small vessel vasculitis associated with systemic disorders
- Causes of secondary CSVV
- Causes of secondary cutaneous vasculitis
- Genetic causes of secondary cutaneous vasculitis
- CSVV differential diagnosis
- Treating CSVV: the general approach
- Mild versus severe CSVV: treatment
- Therapeutic ladder for vasculitis
- Therapeutic ladder for patients with vasculitis
- Therapeutic ladder for patients with vasculitis (continued)
- Therapeutic ladder for patients with vasculitis (continued)
- Therapeutic ladder for patients with vasculitis (continued)
- Therapeutic ladder for patients with vasculitis (continued)
- Therapeutic ladder for patients with vasculitis (continued)
- Therapeutic ladder for patients with vasculitis (continued)
- Therapeutic ladder for patients with vasculitis (continued)
- Therapeutic ladder for patients with vasculitis (continued)
IgA Vasculitis (Henoch-Schonlein Purpura)
The most common vasculitis in children, and its adult presentation
- What is IgA vasculitis
- The classic tetrad of IgA vasculitis
- Epidemiology of IgA vasculitis
- What triggers IgA vasculitis
- Genetic risk factors in IgA vasculitis
- IgA vasculitis (Henoch-Schonlein purpura): clinical spectrum
- Cutaneous features of IgA vasculitis
- Joint and gut involvement in IgA vasculitis
- Kidney involvement in IgA vasculitis
- Long-term outlook, orchitis, and lung disease
- IgA vasculitis in adults versus children
- Pathology of IgA vasculitis
- Direct immunofluorescence in IgA vasculitis
- IgA vasculitis differential diagnosis
- Treating IgA vasculitis: skin and joints
- Treating IgA vasculitis nephritis
Beyond CSVV and IgA Vasculitis
Other subtypes named in the chapter's own classification scheme, and the diagnostic work-up
- Acute hemorrhagic edema of infancy
- Other subtypes named in the classification scheme
- ANCA testing frequency across the ANCA-associated vasculitides
- Diagnostic approach to suspected cutaneous vasculitis
- Key takeaways
- Dermatology, 5th Edition (2-Volume Set)