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The first 25 slides, exactly as they appear. The full deck has 74 content slides.
Dermatology
Autoantibodies Encountered in Patients with Autoimmune Connective Tissue Diseases
Built from Dermatology, 5th Edition
What’s inside
9 sections · 74 slides
Overview
- What this topic covers
What autoantibodies are and why we test for them
Autoimmune connective tissue disease basics
- What is an autoimmune connective tissue disease (AI-CTD)?
- What is an anti-nuclear antibody (ANA)?
The fluorescent ANA test
History, technique, and how to read a result
- Evolution of autoantibody testing
- The fluorescent ANA (FANA) test
- Methods for autoantibody detection
- Why human HEp-2 cells replaced rodent cells
- Why an ANA titer can vary between tests
- Automated immunoassays: ELISA and bead-based tests
- "Normal" versus "abnormal" ANA titers
- Interpreting an ANA result correctly
- Interpreting ANA test results
- Sensitivity, specificity, and predictive value in laboratory testing
- Immunofluorescence patterns on the FANA test
- Immunofluorescence patterns of anti-nuclear antibodies
- Clinical utility of the ANA test in SLE
- 98%
- What autoantibody testing is actually used for
- Sontheimer's corollary to Greenwald's law of lupus
- ANA testing before phototherapy
- Approach to suspected cutaneous lupus erythematosus
Autoantibodies in lupus erythematosus
Which autoantibodies matter, and why
- Autoantibodies and lupus: the big picture
- Autoantibodies associated with lupus erythematosus
- Autoantibodies associated with lupus erythematosus (continued)
- Autoantibodies associated with lupus erythematosus (continued)
- Autoantibodies associated with lupus erythematosus (continued)
- Autoantibodies associated with lupus erythematosus (continued)
- Anti-dsDNA antibodies
- Anti-SSA/Ro and anti-SSB/La antibodies
- Ro52/Ro60 antibody combinations and disease links
- Drug-induced ANA and drug-induced lupus
- Drug-induced subacute cutaneous lupus (SCLE)
- TNF inhibitors and induced autoantibodies
Autoantibodies in dermatomyositis and polymyositis
The idiopathic inflammatory dermatomyopathies
- What are the idiopathic inflammatory dermatomyopathies?
- Autoantibodies in idiopathic inflammatory dermatomyopathies
- Autoantibodies in idiopathic inflammatory dermatomyopathies (continued)
- Autoantibodies in idiopathic inflammatory dermatomyopathies (continued)
- Autoantibodies in idiopathic inflammatory dermatomyopathies (continued)
- Anti-TIF1-γ (p155) and anti-TIF1-α (p140) antibodies
- Anti-MDA5 antibodies (anti-CADM-140)
- Anti-Jo-1 antibodies and antisynthetase syndrome
- Anti-Mi-2, anti-SRP, anti-NXP-2, and anti-SAE antibodies
Autoantibodies in systemic sclerosis and morphea
Scleroderma and localized scleroderma
- What is systemic sclerosis (SSc)?
- Autoantibodies associated with systemic sclerosis
- Anti-RNA polymerase III and cancer-associated scleroderma
- Autoantibodies in morphea (localized scleroderma)
Autoantibodies in other rheumatic disorders and vasculitis
Rheumatoid arthritis, Sjogren syndrome, MCTD, and ANCA
- Autoantibodies in rheumatoid arthritis and Sjogren syndrome
- Autoantibodies associated with other rheumatic diseases having cutaneous manifestations
- Autoantibodies associated with other rheumatic diseases having cutaneous manifestations (continued)
- Mixed connective tissue disease (MCTD)
- Clinical and serologic overlap in autoimmune connective tissue disease
- What are anti-neutrophil cytoplasmic antibodies (ANCA)?
- Two patterns of ANCA and their classic disease links
- Approach to the patient with cytoplasmic ANCA
- Approach to the patient with perinuclear ANCA
- Other diseases linked to ANCA
- Other disorders associated with anti-neutrophil cytoplasmic antibodies (ANCA)
- Other disorders associated with anti-neutrophil cytoplasmic antibodies (ANCA) (continued)
- Other disorders associated with anti-neutrophil cytoplasmic antibodies (ANCA) (continued)
- Other disorders associated with anti-neutrophil cytoplasmic antibodies (ANCA) (continued)
- Other disorders associated with anti-neutrophil cytoplasmic antibodies (ANCA) (continued)
- Other disorders associated with anti-neutrophil cytoplasmic antibodies (ANCA) (continued)
- Diagnostic outcome of positive ANA tests
Summary
Putting the autoantibodies together
- Key takeaways
- Autoantibodies with the highest diagnostic value
References
Sources cited in this chapter
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- Dermatology, 5th Edition (2-Volume Set)