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What is a gene? Describe the parts of a protein-coding region of a gene. Give examples of disorders due to mutations in the non-coding areas of a gene. [2+5+3]
What do you understand by small interfering RNA (siRNA)? Describe its role in health and disease. [3+7]
Describe chromosomal rearrangement and its types. Describe the effects and prediction methods of balanced chromosomal rearrangement in relation to outcome of pregnancy. [5+5]
What is PubMed? How do you use Boolean operators during PubMed search? How do you use single citation matcher? What is the importance of MeSH terms and its use during PubMed search? [2+3+2+3]
What are the various forms of Non-Mendelian inheritance? Describe the mechanism, clinical effects and methods of diagnosis of codominant inheritance and sex linked inheritance. [5+5]
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