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The first 25 slides, exactly as they appear. The full deck has 49 content slides.
Radiology
Russell-Silver Syndrome
Built from Obstetric Imaging
What’s inside
6 sections · 49 slides
Overview
- What this topic covers
The disorder in plain terms
Growth failure that starts in the womb and never catches up
- A baby small from the very start
- Genes can carry a tag saying which parent they came from
- How the syndrome got its double name
- Growth before and after birth
- Why the head looks too big
- How the newborn looks
- Problems that go beyond size
- 1:100,000
Why it happens
Imprinting errors, and single genes that drive growth
- Epigenetics: the switch, not the spelling
- Five molecular routes to the same syndrome
- The commonest cause sits on chromosome 11
- When chromosome 7 comes only from the mother
- Three single-gene causes
- What all the causes share
How it shows at birth
The clinical picture the paediatrician meets
- The picture at birth
- More findings in the newborn
What the ultrasound shows
Growth pattern, bones, face and the ossification clock
- When to think of this on a scan
- The limbs on ultrasound
- The head on ultrasound
- The face on 2D and 3D scanning
- How bone replaces cartilage, and when
- Normal heel bone centre at 20 weeks
- Missing heel bone centre at 24 weeks
- Knee ossification centre on three-dimensional ultrasound
- The curved little finger
- Curved little finger on three-dimensional ultrasound
- Fetal hand with the little finger bending inward
- Normal fluid, normal Doppler - and why that matters
- The combination that should raise the suspicion
- Where MRI fits, and where it does not
- After birth the diagnosis is clinical
- What the radiographs show
- More on the radiographs
- The classic signs at a glance
- The classic signs, spelled out
Look-alikes and what can be done
Narrowing the differential, then testing and treating
- Why the differential matters
- Conditions that can look the same
- Before birth: what can be tested
- In vitro fertilisation and imprinting
- After birth: a team job
- Feeding, gut and jaw
- Hormone treatment
- From suspicion to long-term care
- What the referring physician needs to know
- Key points
- References
- References (continued)
- Obstetric Imaging: Fetal Diagnosis and Care, 2nd Edition