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The first 25 slides, exactly as they appear. The full deck has 46 content slides.
Ophthalmology
Optic Neuritis
Built from Khurana — Neuro-Ophthalmology
What’s inside
6 sections · 46 slides
Overview
- What this deck will teach you
What It Is and How It Presents
Definition, causes and the typical attack
- Optic neuritis: the basic definition
- Where the inflammation comes from
- The three families of causes
- Who gets it and how it starts
- Two classic clinical signs explained
- Swollen optic disc in papillitis
- Papillitis versus retrobulbar neuritis
- How vision recovers
- Typical versus atypical optic neuritis
- Regional and special variants
Investigating the Patient
Ancillary tests, and why the brain MRI is central
- The role of investigations
- Ophthalmic (eye) investigations
- Optical coherence tomography (OCT)
- Systemic investigations — when and why
- Specialised tests for specific suspicions
- Recommendations for MRI of the brain
- Inflamed optic nerve on orbital MRI
- What the brain MRI predicts
- White matter demyelinating lesions in the brain
Telling It Apart
The look-alikes and how to distinguish them
- What else can mimic optic neuritis
- How optic neuritis differs from its mimics
Management and the Landmark Trials
What the evidence says about steroids and preventing MS
- Start with the natural history
- ONTT: how the trial was designed
- ONTT: the three treatment arms
- ONTT: what happened to vision
- ONTT in numbers
- ONTT: the recurrence and MS findings
- ONTT: who is LESS likely to convert to MS
- ONTT: the practical conclusions
- A cheaper alternative: dexamethasone
Preventing MS After the First Attack
The immunomodulator trials — CHAMPS, PRISMS, BENEFIT
- CHAMPS: interferon after a first event
- PRISMS and BENEFIT: more evidence for interferon
- Should we start immunomodulators here?
- Managing optic neuritis that is NOT MS
- Key takeaways
- Why is oral prednisolone alone contraindicated in typical optic neuritis?
- References (1/2)
- References (2/2)
- Neuro-Ophthalmology