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The first 25 slides, exactly as they appear. The full deck has 48 content slides.
Ophthalmology
Demyelinating Disorders and Guillain Barre Syndrome
Built from Khurana — Neuro-Ophthalmology
What’s inside
7 sections · 48 slides
Overview
- What this topic covers
The Foundations
Myelin, and why nerves depend on it
- What is myelin, and why does it matter?
- How myelin speeds up the nerve signal
- Saltatory conduction along a myelinated axon
- What are demyelinating disorders?
Neuromyelitis Optica
Devic disease - the eye-and-spine demyelinator
- Meeting neuromyelitis optica (NMO)
- Who gets NMO? (epidemiology)
- Why NMO happens (pathophysiology)
- How reliable is the NMO antibody test?
- How NMO presents
- The optic neuritis of NMO
- The spinal cord attack of NMO
- Course and prognosis: monophasic vs relapsing
- Relapsing NMO carries a higher death rate
- Why relapsing NMO can be fatal
- Investigating NMO: MRI
- Investigating NMO: CSF and antibodies
- Mayo Clinic diagnostic criteria for NMO (revised 2006)
- Risk factors for a relapsing course
- Multiple sclerosis vs neuromyelitis optica - part 1
- Multiple sclerosis vs neuromyelitis optica - part 2
Managing NMO
Calm the attack, then prevent the next one
- Treating the acute attack
- Preventing relapses: immunosuppressants
- Preventing relapses: newer and rescue options
MS and Diffuse Sclerosis
NMO's demyelinating relatives
- Multiple sclerosis (MS) in brief
- MS: what the eye and body show
- Diffuse sclerosis (Schilder disease)
Guillain-Barre Syndrome
When demyelination strikes the peripheral nerves
- What is Guillain-Barre syndrome (GBS)?
- What triggers GBS?
- The GBS family of subtypes
Miller Fisher Syndrome
The eye-predominant variant of GBS
- Miller Fisher syndrome (MFS): the clinical triad
- MFS: the eyes and pupils
- Why MFS happens: the anti-GQ1b antibody
- Structure of the GQ1b ganglioside
- MFS: sorting it from its mimics
- MFS: management and outcome
- Three things to remember
- References (1/3)
- References (2/3)
- References (3/3)
- Neuro-Ophthalmology