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Radiology

Central Nervous System Infections

Built from Fundamentals of Diagnostic Radiology

What’s inside

6 sections · 149 slides

  1. 01

    Overview

    • The landscape of CNS infections
    • 30–70%
    • Choosing CT versus MRI

    3 slides

  2. 02

    Congenital Infections

    TORCH pathogens cross the placenta and injure the developing brain

    • TORCH: the congenital infection group
    • What TORCH means
    • Cytomegalovirus: the most common one
    • CMV: periventricular injury
    • Congenital CMV: periventricular calcifications
    • CMV: early infection disturbs brain formation
    • Toxoplasmosis: second in frequency
    • Toxoplasmosis: scattered calcifications
    • Congenital toxoplasmosis: scattered calcifications
    • Lymphocytic choriomeningitis virus
    • Neonatal herpes encephalitis
    • Neonatal herpes: imaging findings
    • Neonatal herpes encephalitis on CT
    • Congenital HIV
    • Congenital rubella
    • Congenital rubella: basal ganglia calcifications
    • Zika virus infection
    • Congenital Zika: calcifications and cortical malformation
    • Zika: MRI features and screening

    19 slides

  3. 03

    Extra-axial Infections

    Epidural and subdural collections plus meningitis, outside the brain

    • Epidural and subdural empyemas
    • Epidural abscess on contrast CT
    • Epidural versus subdural collections
    • Complications and DWI clues
    • Subdural empyema on MRI
    • Benign meningeal enhancement after surgery
    • Benign postoperative meningeal enhancement
    • Bacterial meningitis: the organisms
    • Bacterial meningitis by age group
    • Bacterial meningitis: presentation
    • Bacterial meningitis: early and late CT
    • Bacterial meningitis: complications
    • Subdural effusion in H. influenzae meningitis
    • Tuberculous meningitis: clinical picture
    • Tuberculous meningitis: imaging
    • Tuberculous meningitis: basal cistern enhancement
    • TB meningitis: vascular complications
    • Fungal meningitis
    • Coccidioidomycosis meningitis on MRI
    • Racemose (meningobasal) cysticercosis
    • Racemose cysticercosis in the sylvian fissure
    • Intraventricular cysticercosis
    • Intraventricular cysticercosis
    • Viral meningitis
    • Neurosarcoidosis
    • Neurosarcoidosis: leptomeningeal enhancement

    26 slides

  4. 04

    Parenchymal Infections

    Infection inside the brain: cerebritis, abscess, granuloma, and encephalitis

    • How pyogenic brain infections arise
    • Where abscesses form
    • Clinical features of brain abscess
    • Treatment of pyogenic abscess
    • Four stages of cerebritis and abscess
    • Early cerebritis
    • Evolution from cerebritis to abscess
    • Late cerebritis
    • Late cerebritis on contrast CT
    • Early capsule
    • Late capsule
    • Multiple pyogenic abscesses
    • Pyogenic cerebral abscess: classic MRI features
    • Ventricular rupture risk
    • Abscess differential diagnosis
    • Septic embolus
    • Tuberculoma and tuberculous abscess
    • Tuberculoma: clinical picture
    • Tuberculoma: imaging
    • Multiple tuberculomas
    • Tuberculous abscess
    • Endemic versus opportunistic fungi
    • Endemic fungal infections
    • Fungal granuloma imaging
    • Histoplasmosis granuloma
    • Opportunistic fungal infections
    • Aspergillosis
    • Disseminated aspergillosis: necrotic mass
    • Aspergillosis: T2-hypointense lesions
    • Mucormycosis
    • Mucormycosis with sinus invasion
    • Candidiasis
    • Cryptococcosis
    • Cryptococcosis: imaging
    • Parasitic infections overview
    • Cysticercosis: the parasite
    • Cysticercosis: clinical picture
    • Parenchymal cysticercosis: four stages
    • Cysticercosis: staging details
    • Cysticercosis: vesicular stage
    • Cysticercosis: colloid stage with scolex
    • Late-stage calcified cysticercosis
    • Spinal and extra-axial cysticercosis
    • Echinococcosis (hydatid disease)
    • Toxoplasmosis (acquired)
    • Amebic meningoencephalitis
    • Granulomatous amebic encephalitis
    • Neurosyphilis
    • Meningovascular syphilis
    • Meningovascular syphilis
    • Lyme disease
    • Lyme disease: parenchymal imaging
    • Herpes simplex encephalitis
    • HSV encephalitis: imaging pattern
    • Adult HSV1 encephalitis on CT
    • HSV1 encephalitis: FLAIR pattern
    • HSV1 encephalitis: FLAIR, DWI, and late enhancement
    • Varicella zoster virus (VZV)
    • Cytomegalovirus encephalitis
    • Subacute sclerosing panencephalitis (SSPE)
    • SSPE: reduced diffusion on ADC maps
    • Arboviral and other encephalitides
    • West Nile encephalitis: thalamic signal
    • Rasmussen encephalitis
    • Cerebellitis: causes and clinical picture
    • Cerebellitis: imaging
    • Cerebellitis on MRI
    • Acute disseminated encephalomyelitis (ADEM)
    • ADEM: white matter lesions on FLAIR
    • ADEM: imaging and variants

    70 slides

  5. 05

    Creutzfeldt-Jakob Disease

    A prion disease that rapidly destroys the brain

    • Creutzfeldt-Jakob disease: the prion
    • Sporadic CJD: imaging
    • CJD: cortical ribbon on DWI
    • New variant CJD

    4 slides

  6. 06

    AIDS-Related Infections

    Opportunistic infections and lymphoma in the immunocompromised brain

    • AIDS and the CNS
    • The AIDS brain differential
    • HIV encephalopathy
    • HIV encephalopathy: imaging
    • AIDS-related cerebral atrophy
    • HIV encephalopathy: white matter signal
    • CNS toxoplasmosis in AIDS
    • Toxoplasmosis: imaging appearance
    • Toxoplasmosis: ring-enhancing lesions
    • Toxoplasmosis before and after treatment
    • Fungal meningitis in AIDS
    • Cryptococcal pseudocysts
    • Cryptococcosis and toxoplasmosis
    • Progressive multifocal leukoencephalopathy
    • PML: imaging
    • PML: corona radiata lesion
    • CMV and other viral infections in AIDS
    • Mycobacterial infections in AIDS
    • Primary CNS lymphoma in AIDS
    • Primary CNS lymphoma on CT
    • Toxoplasmosis versus lymphoma in AIDS
    • Key takeaways
    • References
    • References (continued)
    • References (continued)
    • References (continued)
    • Brant and Helms' Fundamentals of Diagnostic Radiology

    27 slides