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Dermatology
Palmoplantar Keratodermas
Built from Dermatology, 5th Edition
What’s inside
10 sections · 135 slides
Overview
- What this topic covers
Introduction and Classification
What PPK is, how it is grouped, and how it is worked up
- Palmoplantar keratoderma: definition
- Inherited versus acquired PPK
- Three patterns of involvement
- Diffuse palmoplantar keratoderma
- Focal palmoplantar keratoderma
- Punctate palmoplantar keratoderma
- Diffuse palmar keratoderma, close view
- Punctate keratosis, coalescing lesions
- Extra descriptive terms
- Digital constriction bands (pseudoainhum)
- Genodermatoses associated with digital constriction bands (pseudoainhum)
- Clinical work-up of a patient with PPK
- Primary palmoplantar keratodermas (PPKs)
- Primary palmoplantar keratodermas (PPKs) (continued)
- Primary palmoplantar keratodermas (PPKs) (continued)
- Primary palmoplantar keratodermas (PPKs) (continued)
- Primary palmoplantar keratodermas (PPKs) (continued)
- Primary palmoplantar keratodermas (PPKs) (continued)
- Primary palmoplantar keratodermas (PPKs) (continued)
- Primary palmoplantar keratodermas (PPKs) (continued)
- Primary palmoplantar keratodermas (PPKs) (continued)
- Primary palmoplantar keratodermas (PPKs) (continued)
- Primary palmoplantar keratodermas (PPKs) (continued)
- Primary palmoplantar keratodermas (PPKs) (continued)
- Primary palmoplantar keratodermas (PPKs) (continued)
- PPK as part of another genetic skin disease
- Other genodermatoses that feature palmoplantar keratoderma (PPK)
- Other genodermatoses that feature palmoplantar keratoderma (PPK) (continued)
- Other genodermatoses that feature palmoplantar keratoderma (PPK) (continued)
- Skin biopsy: what it can show
- Histologic patterns in selected hereditary palmoplantar keratodermas (PPKs)
- Histologic patterns in selected hereditary palmoplantar keratodermas (PPKs) (continued)
- Histologic patterns in selected hereditary palmoplantar keratodermas (PPKs) (continued)
- The gap junction and connexins
- Connexin channels and the gap junction plaque
- Human connexin disorders
- Human connexin disorders (continued)
- Human connexin disorders (continued)
- Genetic mutations behind hereditary PPKs
- Genetic mutations underlying hereditary palmoplantar keratodermas
Diffuse PPK Without Associated Features
Isolated, non-syndromic forms - epidermolytic and non-epidermolytic
- Diffuse epidermolytic PPK (Vorner-Unna-Thost): overview
- EPPK: how the mutation causes disease
- EPPK: clinical course
- Diffuse epidermolytic PPK (Vorner-Unna-Thost)
- Diffuse epidermolytic PPK, sole involvement
- EPPK: what the biopsy shows
- Histologic features of palmoplantar keratoderma
- EPPK: diagnosis and management
- Diffuse non-epidermolytic PPK (NEPPK): overview
- NEPPK subtypes: genes and mechanism
- Mal de Meleda
- Mal de Meleda
- NEPPK: biopsy and treatment
- Keratolytic winter erythema and CTSB-related PPK
- Keratolytic winter erythema
Diffuse PPK With Ichthyosis
Loricrin keratoderma and KLICK syndrome
- Loricrin keratoderma
- Loricrin keratoderma vs Vohwinkel syndrome
- KLICK syndrome
- KLICK syndrome
Diffuse PPK With Associated Features
Syndromic diffuse PPK - hearing loss, cancer risk, hair and nail change, cardiomyopathy
- Vohwinkel syndrome: genetics and skin findings
- Mutilating palmoplantar keratoderma in Vohwinkel syndrome
- Vohwinkel syndrome: hearing and treatment
- Bart-Pumphrey syndrome
- Bart-Pumphrey syndrome
- Mitochondrial PPK with hearing impairment
- Huriez syndrome
- Huriez syndrome
- PPK with sex reversal and squamous cell carcinoma
- Clouston syndrome
- Clouston syndrome
- Odonto-onycho-dermal dysplasia (Schopf-Schulz-Passarge)
- Olmsted syndrome
- Olmsted syndrome: treatment insight
- Papillon-Lefevre and Haim-Munk syndromes
- Naxos disease
- The PPK - woolly hair - cardiomyopathy triad
Focal PPK Without Associated Features
Striate/focal PPK - a desmosome and keratin disorder
- Striate (focal) palmoplantar keratoderma
- Striate and areata focal palmoplantar keratoderma
- Striate PPK: related conditions and treatment
Focal PPK With Associated Features
Pachyonychia congenita, Richner-Hanhart, Howel-Evans, and Carvajal syndromes
- Pachyonychia congenita: overview
- >90%
- Pachyonychia congenita: nail and skin findings
- Pachyonychia congenita
- Pachyonychia congenita, nail and sole detail
- Pachyonychia congenita: other features and treatment
- Richner-Hanhart syndrome (tyrosinemia type II)
- Richner-Hanhart syndrome (tyrosinemia II)
- Richner-Hanhart syndrome, corneal findings
- Richner-Hanhart syndrome: treatment
- Howel-Evans syndrome
- Howel-Evans syndrome
- Carvajal syndrome
- Carvajal syndrome
Punctate PPK Without Associated Features
Buschke-Fischer-Brauer type, spiny keratoderma, and marginal papular keratoderma
- Punctate PPK, Buschke-Fischer-Brauer type
- Punctate PPK: course and work-up
- Punctate keratoses of the palmar creases
- Punctate keratoses of the palmar creases
- Conditions causing palmoplantar pits
- Differential diagnosis of palmoplantar pits
- Spiny keratoderma
- Spiny palmoplantar keratoderma
- Marginal papular keratoderma
- Marginal papular keratoderma
- Marginal papular keratoderma, close view
- Focal acral hyperkeratosis: histology
Punctate PPK With Associated Features
Cole disease and PLACK syndrome
- Cole disease
- PLACK syndrome
Acquired Keratodermas
PPK that develops later in life - drugs, cancer, hormones, and idiopathic forms
- Keratoderma climactericum
- Keratoderma climactericum
- PPK and internal cancer
- Arsenical keratoses
- Other acquired causes
- Aquagenic palmoplantar keratoderma
- Aquagenic wrinkling of the palms
- Aquagenic keratoderma, pebbly change
- Aquagenic PPK: treatment
- Circumscribed palmar or plantar hypokeratosis
- Circumscribed palmar hypokeratosis
- Circumscribed hypokeratosis: treatment
- Diffuse PPK in a related ichthyosis syndrome
- Diffuse palmar keratoderma in an infant with KID syndrome
- A related erosive skin fragility disorder
- Palmar keratoderma in ectodermal dysplasia-skin fragility syndrome
- How to approach a PPK patient
- Key takeaways
- References
- References (continued)
- References (continued)
- References (continued)
- References (continued)
- References (continued)
- References (continued)
- References (continued)
- Dermatology, 5th Edition (2-Volume Set)