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Dermatology
Neutrophilic Dermatoses
Built from Dermatology, 5th Edition
What’s inside
8 sections · 154 slides
Overview
- What this topic covers
- Definition of a neutrophilic dermatosis
- Spectrum of non-infectious neutrophilic dermatoses
- Neutrophilic dermatoses in autoinflammatory disease
Neutrophil Biology
Where neutrophils come from, how they travel to injury, and why their weapons can harm the host
- Basic neutrophil function
- Neutrophil production and lifespan
- Three types of neutrophil granules
- From bloodstream to battle
- Neutrophils and sites of inflammation
- Neutrophils and sites of inflammation (continued)
- Neutrophil trafficking to a site of injury
- Cytokines that drive neutrophilic inflammation
- Neutrophil-mediated tissue injury
Sweet Syndrome
Sudden fever with tender red plaques, and the prototype of the neutrophilic dermatoses
- Sweet syndrome: key features
- History of Sweet syndrome
- Epidemiology of Sweet syndrome
- Triggers of Sweet syndrome
- Sweet syndrome: infectious and malignant triggers
- Sweet syndrome - infectious, malignant and bowel-disease triggers
- Sweet syndrome: drug triggers
- Sweet syndrome - drug and other associations
- Pathogenesis of Sweet syndrome
- Sweet syndrome lesion morphology
- Distribution of Sweet syndrome lesions
- Sweet syndrome mimicking infection
- Clinical variants of Sweet syndrome
- Ocular involvement in Sweet syndrome
- Course of the cutaneous eruption
- Sweet syndrome plaques in acute myeloid leukemia
- Systemic manifestations of Sweet syndrome
- Systemic manifestations of Sweet syndrome by frequency
- Typical histology of Sweet syndrome
- Sweet syndrome histopathology
- Histologic variants of Sweet syndrome
- Histiocytoid Sweet syndrome histopathology
- Histiocytoid Sweet syndrome in acute myeloid leukemia
- Diagnosis of Sweet syndrome
- Criteria for diagnosis of Sweet syndrome
- Sweet syndrome mimics
- Differential diagnosis of Sweet syndrome
- Neutrophilic dermatosis of the dorsal hands
- Neutrophilic dermatosis of the dorsal hands: clinical and necrotizing forms
- Neutrophilic dermatosis of the dorsal hands: additional case
- Three neutrophilic dermatoses seen with blood cancers
- Hematologic-malignancy-associated neutrophilic dermatoses — Sweet syndrome
- Hematologic-malignancy-associated neutrophilic dermatoses — Atypical (bullous) pyoderma gangrenosum
- Hematologic-malignancy-associated neutrophilic dermatoses — Neutrophilic eccrine hidradenitis
- Treatment of Sweet syndrome
- Alternatives to corticosteroids for Sweet syndrome
Pyoderma Gangrenosum
An expanding, undermined skin ulcer that is frequently mistaken for infection
- Pyoderma gangrenosum: key features
- History of pyoderma gangrenosum
- Epidemiology of pyoderma gangrenosum
- Pathogenesis of pyoderma gangrenosum
- IL-1-driven inflammation in pyoderma gangrenosum
- Pathergy in pyoderma gangrenosum
- Four major clinical forms of pyoderma gangrenosum
- Clinical variants of pyoderma gangrenosum
- Bullous pyoderma gangrenosum
- Mucosal and vegetative variants of pyoderma gangrenosum
- Evolution of the pyoderma gangrenosum ulcer
- Pyoderma gangrenosum: clinical presentations
- Classic ulcerative pyoderma gangrenosum on the shin
- Undermined, violaceous border in pyoderma gangrenosum (case 1)
- Undermined, violaceous border in pyoderma gangrenosum (case 2)
- Earliest lesion in pyoderma gangrenosum
- Clinical course by underlying cause
- Peristomal and postsurgical pyoderma gangrenosum
- Peristomal pyoderma gangrenosum around an ileostomy (second case)
- Diseases associated with pyoderma gangrenosum
- Pyoderma gangrenosum with IgA monoclonal gammopathy
- PAPA syndrome and pyoderma gangrenosum
- Pyoderma gangrenosum in PAPA syndrome
- Histology of pyoderma gangrenosum
- Pyoderma gangrenosum histopathology
- Vegetative, pustular ulcer base in pyoderma gangrenosum
- Misdiagnosis of pyoderma gangrenosum
- Pyoderma gangrenosum diagnosis — Su Criteria
- Pyoderma gangrenosum diagnosis — PARACELSUS Score
- Pyoderma gangrenosum diagnosis — Delphi Consensus Criteria
- Pyoderma gangrenosum: evaluation approach
- Evaluation of a patient with presumed pyoderma gangrenosum
- Pyoderma gangrenosum look-alikes by stage
- Differential diagnosis of pyoderma gangrenosum
- Pustular variant of pyoderma gangrenosum
- Treatment principles for pyoderma gangrenosum
- Managing long corticosteroid courses
- Treatment ladder for pyoderma gangrenosum
- Therapeutic ladder for pyoderma gangrenosum
- Therapeutic ladder for pyoderma gangrenosum (continued)
- Therapeutic ladder for pyoderma gangrenosum (continued)
- Therapeutic ladder for pyoderma gangrenosum (continued)
- Therapeutic ladder for pyoderma gangrenosum (continued)
- Therapeutic ladder for pyoderma gangrenosum (continued)
- Therapeutic ladder for pyoderma gangrenosum (continued)
Behçet Disease
A multisystem disease of recurrent mouth and genital ulcers, eye inflammation, and vessel disease
- Behçet disease: key features
- History of Behçet disease
- Epidemiology of Behçet disease
- Pathogenesis of Behçet disease
- Oral ulcers in Behçet disease
- Mucocutaneous lesions in Behçet disease
- Genital and skin lesions in Behçet disease
- Perianal aphthosis in Behçet disease
- Lower extremity ulcerations in Behçet disease
- Oral ulcerations of the soft palate and tongue in Behçet disease
- Systemic involvement in Behçet disease
- Organ systems affected in Behçet disease
- Ocular and cutaneous vasculitic involvement in Behçet disease
- Systemic manifestations of Behçet disease
- Systemic manifestations of Behçet disease (continued)
- Behçet disease versus bowel-linked neutrophilic disease
- Neutrophilic dermatoses associated with bowel disorders
- Neutrophilic dermatoses associated with bowel disorders (continued)
- Gastrointestinal pathology in Behçet disease, BADAS, and IBD
- Histology of Behçet disease skin lesions
- Diagnosing Behçet disease
- International Study Group criteria for Behçet disease
- Treating Behçet disease
- Therapeutic ladder for Behçet disease
- Therapeutic ladder for Behçet disease (continued)
- Therapeutic ladder for Behçet disease (continued)
Bowel-Associated Dermatosis-Arthritis Syndrome
A serum-sickness-like reaction (BADAS) to bacterial overgrowth after bowel surgery or disease
- BADAS: key features
- History and cause of BADAS
- Conditions associated with bowel-associated dermatosis-arthritis syndrome
- Clinical features of BADAS
- Papules and papulopustules in bowel-associated dermatosis-arthritis syndrome
- Systemic complications of BADAS
- Papulopustules of bowel-associated dermatosis-arthritis syndrome on the arm
- Pathology and differential diagnosis of BADAS
- Treating BADAS
- Therapeutic approaches for bowel-associated dermatosis-arthritis syndrome
SAPHO Syndrome
Synovitis, acne, pustulosis, hyperostosis, and osteitis - bone and joint disease with a pustular rash
- SAPHO syndrome: key features
- History and epidemiology of SAPHO syndrome
- Pathogenesis and clinical picture of SAPHO syndrome
- Diagnosing and imaging SAPHO syndrome
- SAPHO syndrome
- Pathology, differential diagnosis, and treatment of SAPHO
Erosive Pustular Dermatosis
Sterile scalp pustules and erosions in fragile, sun-damaged skin
- Erosive pustular dermatosis: key features
- History, epidemiology, and cause of erosive pustular dermatosis
- Clinical features of erosive pustular dermatosis
- Pathology and differential diagnosis of erosive pustular dermatosis
- Treating erosive pustular dermatosis
- Six neutrophilic dermatoses at a glance
- Three more neutrophilic dermatoses at a glance
- Key takeaways
- References
- References (continued)
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- References (continued)
- Dermatology, 5th Edition (2-Volume Set)