← All decks
Dermatology
Cutaneous Metastases
Built from Dermatology, 5th Edition
What’s inside
8 sections · 68 slides
Overview
- What this topic covers
Introduction and Epidemiology
What cutaneous metastases are, and how often they occur
- What is a cutaneous metastasis
- A metastasis mimicking an epidermoid cyst
- How common are cutaneous metastases
- Cutaneous metastases in patients with metastatic cancer.
- Cutaneous metastases in patients with metastatic cancer. (continued)
- Sex differences in cutaneous metastases
- Subcutaneous metastasis of small cell lung carcinoma
- Overall cancer prevalence shapes the numbers
- Timing and prognostic significance
Pathogenesis
How tumor cells travel from the primary site to the skin
- The "seed and soil" hypothesis
- The metastatic cascade
- Two models of how metastatic ability develops
- Why metastases favor certain tissues
Clinical Features
Color, firmness, and location patterns that point to the diagnosis
- The classic clinical presentation
- Where cutaneous metastases occur
- Anatomic locations of cutaneous metastases.
- Color and firmness as clinical clues
- The clinical color spectrum of cutaneous metastases
- Three routes tumor cells take to the skin
- Proximity to the primary tumor as a clue
- Colon carcinoma metastases along a surgical scar
- Sister Mary Joseph nodule
- Sister Mary Joseph nodule from colon carcinoma
- Breast carcinoma: the widest range of presentations
- Clinical presentations of cutaneous metastases and histologic correlates.
- Clinical presentations of cutaneous metastases and histologic correlates. (continued)
- Clinical patterns of breast carcinoma metastasis
- "En cuirasse" and inflammatory carcinoma
- An ulcerated nodule of metastatic breast carcinoma
- Melanoma: firm, often pigmented papules
- Clustered melanoma metastases in the axilla
- Multiple melanoma metastases on the leg
- Renal cell carcinoma: a vascular-tumor mimic
- A firm, telangiectatic scalp papule from renal cell carcinoma
- Scalp metastases and alopecia neoplastica
- Alopecia neoplastica from renal cell carcinoma
- Alopecia neoplastica from signet ring adenocarcinoma
- Scalp metastases of breast carcinoma
- When the primary cancer is unknown
- Metastasis of signet ring adenocarcinoma of unknown primary
- Less common and dermatosis-mimicking patterns
- Paget disease: mammary and extramammary
- Leukemia and lymphoma in the skin
Pathology
Histologic patterns and the immunohistochemical clues that identify the source
- Three major tumor categories
- Four histopathologic patterns
- The four major histologic patterns
- Histologic clue: renal cell carcinoma
- Clear cell renal cell carcinoma in the skin
- Histologic clue: signet ring cells
- Signet ring cell morphology in breast and gastric metastases
- Other histologic clues to the source tumor
- Histologic clues to the diagnosis of cutaneous metastases.
- Epidermotropism and pigmented mimics
- Intravascular and intralymphatic spread
- Distinguishing a metastasis from a primary skin tumor
- Pathologic findings and markers in cutaneous metastases
- CK7/CK20 and organ-restricted markers
- An algorithm for immunohistochemical diagnosis
- Confirming the diagnosis in practice
Treatment and Prognosis
Outcomes, and the multidisciplinary approach to management
- Prognosis after a cutaneous metastasis
- A multidisciplinary approach to management
- Managing a malodorous tumor
Summary
Pulling the key facts about cutaneous metastases together
- Key takeaways
References
Source citations from the chapter
- References
- References (continued)
- References (continued)
- Dermatology, 5th Edition (2-Volume Set)