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Dermatology

Benign Epidermal Tumors and Proliferations

Built from Dermatology, 5th Edition

What’s inside

6 sections · 147 slides

  1. 01

    Overview

    • What this topic covers
    • Classifying the benign epidermal proliferations

    2 slides

  2. 02

    Lentigines and Keratoses

    Solar lentigo, seborrheic keratosis, lichenoid keratosis, dermatosis papulosa nigra, stucco keratosis

    • Solar lentigo
    • Solar lentigo - who gets it and why
    • Solar lentigo - clinical appearance
    • PUVA lentigo and xeroderma pigmentosum
    • Dermoscopy and histology of solar lentigo
    • Solar lentigo - telling it apart, and treatment
    • Seborrheic keratosis
    • Seborrheic keratosis - background and risk
    • Seborrheic keratosis - how it forms (1)
    • Seborrheic keratosis - how it forms (2)
    • From sun damage to a keratotic plaque
    • Seborrheic keratosis - clinical appearance
    • Seborrheic keratoses on the back and chest
    • Seborrheic keratoses of varying size and color
    • Seborrheic keratosis and internal cancer
    • Sign of Leser-Trelat
    • How a paraneoplastic sign tracks a hidden tumor
    • Six histologic patterns of seborrheic keratosis
    • Seborrheic keratosis - spectrum of histologic subtypes
    • Seborrheic keratosis - lookalikes (1)
    • Seborrheic keratosis - lookalikes (2)
    • Seborrheic keratosis - treatment
    • Lichenoid keratosis
    • Lichenoid keratosis - who gets it and why
    • Lichenoid keratosis - clinical appearance
    • Lichenoid keratosis under the microscope
    • Lichenoid keratosis - pathology and lookalikes
    • Dermatosis papulosa nigra
    • Dermatosis papulosa nigra - clinical appearance and cause
    • Dermatosis papulosa nigra - facial distribution
    • Dermatosis papulosa nigra - pathology and treatment
    • Stucco keratosis
    • Stucco keratosis - who gets it and why
    • Stucco keratosis - clinical appearance
    • Stucco keratoses on the ankle and foot
    • Stucco keratosis - lookalikes and treatment

    36 slides

  3. 03

    Porokeratosis and Related Keratotic Disorders

    Porokeratosis and its variants, Flegel disease, acrokeratosis verruciformis, cutaneous horn

    • Porokeratosis
    • Porokeratosis - name and mechanism
    • Porokeratosis - discovery timeline
    • Porokeratosis - who gets which type
    • Porokeratosis - the broken pathway
    • Enzymes of the mevalonate pathway in porokeratosis
    • A germline gene fault plus a second hit
    • From a faulty gene to a keratotic rim
    • Porokeratosis of Mibelli and DSAP
    • Porokeratosis - how the variants spread
    • Distinguishing DSAP from actinic keratosis on the legs
    • Other clinical variants of porokeratosis
    • Porokeratosis - the range of clinical variants
    • Clinical variants of porokeratosis
    • Clinical variants of porokeratosis (continued)
    • Porokeratosis - the cornoid lamella under the microscope
    • Cornoid lamella on biopsy
    • Cornoid lamella - absent granular layer
    • Disseminated superficial actinic porokeratosis on the shins
    • Dermoscopy of the keratotic rim in DSAP
    • Linear porokeratosis with coexisting DSAP
    • Linear porokeratosis - reticular streaks
    • Actinic porokeratosis after organ transplant
    • Eruptive disseminated porokeratosis
    • Porokeratosis - lookalikes and cancer risk
    • Porokeratosis - treatment
    • Flegel disease
    • Flegel disease - clinical appearance and pathology
    • Flegel disease on the shins
    • Flegel disease - lookalikes and treatment
    • Acrokeratosis verruciformis of Hopf
    • Acrokeratosis verruciformis - pathology and treatment
    • Cutaneous horn
    • Cutaneous horn arising from an actinic keratosis
    • Cutaneous horn - treatment

    35 slides

  4. 04

    Epidermal Acanthomas

    Clear cell, inverted follicular, warty, acantholytic, epidermolytic, and large cell acanthoma

    • Clear cell acanthoma
    • Clear cell acanthoma - cause and appearance
    • Clear cell acanthoma - clinical and pathologic appearance
    • Clear cell acanthoma - lookalikes and treatment
    • Inverted follicular keratosis
    • Inverted follicular keratosis under the microscope
    • Inverted follicular keratosis - lookalikes
    • Warty dyskeratoma
    • Warty dyskeratoma - a cup-shaped invagination
    • Warty dyskeratoma - lookalikes and treatment
    • Acantholytic (dyskeratotic) acanthoma
    • Epidermolytic acanthoma
    • Solitary epidermolytic acanthoma
    • Epidermolytic acanthoma - lookalikes and treatment
    • Large cell acanthoma
    • Large cell acanthoma - clinical and pathologic appearance
    • Large cell acanthoma - enlarged keratinocytes

    17 slides

  5. 05

    Nevi and Hamartomas Along the Lines of Blaschko

    Epidermal nevus, inflammatory linear verrucous epidermal nevus (ILVEN), nevus comedonicus

    • What "nevus" means in dermatology
    • Epidermal nevus
    • 1 in 1000
    • Epidermal nevus - clinical appearance
    • Epidermal nevus on the eyelid
    • Epidermal nevus syndrome
    • Epidermal nevus - how common are other anomalies
    • Epidermal nevus - pathology, lookalikes, and treatment
    • Inflammatory linear verrucous epidermal nevus
    • ILVEN - the genes involved
    • ILVEN - clinical appearance
    • ILVEN on the thigh
    • ILVEN following the lines of Blaschko
    • ILVEN - lookalikes
    • ILVEN - treatment options
    • Nevus comedonicus
    • Nevus comedonicus - the genes involved
    • Nevus comedonicus - clinical appearance
    • Nevus comedonicus - lookalikes and treatment
    • A shared molecular thread
    • Somatic activating mutations in benign epidermal tumors
    • Somatic activating mutations in benign epidermal tumors (continued)

    22 slides

  6. 06

    Papillomatous and Pigmentary Epidermal Proliferations

    Acanthosis nigricans, nevoid hyperkeratosis of the nipple, confluent and reticulated papillomatosis, terra firma-forme dermatosis, clear cell papulosis

    • Acanthosis nigricans
    • Nevoid hyperkeratosis of the nipple and areola
    • Nevoid hyperkeratosis of the areola
    • Nevoid hyperkeratosis of the nipple - treatment
    • Confluent and reticulated papillomatosis
    • CARP - what causes it
    • CARP - clinical appearance
    • CARP - reticulated papules on the back
    • CARP on the chest
    • CARP on the chest and neck
    • CARP - pathology and lookalikes
    • ~50%
    • CARP - treatment options
    • Terra firma-forme dermatosis
    • Clear cell papulosis
    • Clear cell papulosis - pathology, lookalikes, and outcome
    • Putting it together (1)
    • Putting it together (2)
    • References
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    • References (continued)
    • Dermatology, 5th Edition (2-Volume Set)

    35 slides