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Dermatology
Amyloidosis
Built from Dermatology, 5th Edition
What’s inside
12 sections · 89 slides
Overview
- What this deck covers
Introduction & classification
What amyloid is, its history, how common it is, and how it is grouped
- What amyloidosis is
- Two ways dermatologists meet amyloidosis
- Approaching amyloidosis involving the skin
- History of amyloid
- How common is amyloidosis
- Two ways to classify amyloidosis
- Clinical classification of amyloidosis
- Reading the chemical classification table
- Chemical classification of amyloidoses
- Chemical classification of amyloidoses (continued)
- Chemical classification of amyloidoses (continued)
- Chemical classification of amyloidoses (continued)
- Amyloid, grouped by its precursor protein
Pathogenesis & amyloid properties
How normal proteins misfold into amyloid, and how pathologists identify it
- How amyloid forms
- What drives primary cutaneous amyloid
- Nodular amyloidosis has a different origin
- Amyloid's structural signature
- Cross-beta-pleated sheet structure of amyloid fibrils
- Histologic and ultrastructural features of amyloid
- Special stains that identify amyloid deposits
- Histopathologic features of amyloid deposits 2
Macular and lichen amyloidosis
The itchy, pigmented skin-only forms, and how they differ
- Macular, lichen, and biphasic amyloidosis
- Macular amyloidosis
- Macular amyloidosis - clinical and histologic features
- Friction and notalgia paresthetica overlap
- Lichen amyloidosis
- Lichen amyloidosis of the shins and calves
- Lichen amyloidosis in a linear array
- Lichen amyloidosis of the forearm
- Lichen amyloidosis of the legs
- Lichen amyloidosis of the extensor arms
- Unusual sites and disease associations
- Cutaneous amyloidosis in systemic sclerosis
Familial cutaneous amyloidosis syndromes
Inherited gene changes that predispose to skin-only amyloid deposits
- Genes behind familial skin amyloidosis
- Familial cutaneous amyloidosis, by gene
- IL-31 receptor-associated amyloidosis
- Dyschromic amyloidosis
- Dyschromic amyloidosis cutis
- Sipple syndrome (MEN type 2A)
- Partington amyloidosis (X-linked)
- Other associations and drug-triggered amyloid
- Anakinra-associated amyloidosis at an injection site
Nodular amyloidosis
The rarest cutaneous form, and why it needs long-term follow-up
- Nodular amyloidosis - clinical features
- Nodular amyloidosis - clinical and histologic features
- Nodular amyloidosis of the plantar surface
- Nodular amyloidosis papules of the sole
- Does nodular amyloidosis progress to systemic disease
Pathology & differential diagnosis
What biopsies show, and the look-alike conditions to rule out
- Pathology of macular and lichen amyloidosis
- Macular amyloidosis on histology
- Pathology of nodular amyloidosis
- Look-alikes for macular amyloidosis
- Look-alikes for lichen amyloidosis
- Look-alikes for nodular amyloidosis
Treating cutaneous amyloidosis
Breaking the itch-scratch cycle, since no cure yet exists
- Principles of treating macular and lichen amyloidosis
- Treatment of macular and lichen amyloidosis
- Escalating therapy for macular and lichen amyloidosis
- More treatment options, ranked by evidence
- Treating nodular amyloidosis
Secondary cutaneous amyloidosis
Amyloid found by accident inside unrelated skin growths
- Secondary cutaneous amyloidosis
- Hypotrichosis simplex of the scalp
Primary systemic (AL) amyloidosis
A life-threatening plasma cell disease, and how it shows up in skin
- AL amyloidosis - the basics
- Oral cavity findings in AL amyloidosis
- Mucocutaneous findings in primary systemic AL amyloidosis
- Macroglossia and tongue papulonodules in AL amyloidosis
- Purpura - bruising from fragile vessels
- Periorbital purpura in AL amyloidosis
- Waxy papules and plaques in AL amyloidosis
- Waxy translucent facial papules in AL amyloidosis
- Other skin and nail changes in AL amyloidosis
- Organ involvement beyond the skin
- Confirming the diagnosis of AL amyloidosis
- Evaluating a patient with suspected AL amyloidosis
- Pathology of AL amyloidosis in the skin
- Perivascular amyloid deposits on histology
- Differential diagnosis of AL amyloidosis
- Treating AL amyloidosis
Secondary systemic (AA) amyloidosis
Amyloid triggered by long-standing inflammation or infection
- Two forms of systemic amyloidosis, at a glance
- AA amyloidosis
- Treating AA amyloidosis
Other systemic and inherited amyloidoses
Dialysis-related and inherited forms
- Hemodialysis-associated amyloidosis
- Finnish-type familial amyloidosis (AGel)
- Transthyretin (ATTR) amyloidosis
- Treating ATTR amyloidosis
- Key takeaways
- References
- References (continued)
- References (continued)
- Dermatology, 5th Edition (2-Volume Set)